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Traditional Uses and Cultivation of St. John’s Wort (Hypericum perforatum L.) in Türkiye

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Medicinal and Aromatic Plants of Turkey

Part of the book series: Medicinal and Aromatic Plants of the World ((MAPW,volume 10))

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Abstract

Hypericum perforatum L., is a widely known and used species worldwide. Belonging to the Hypericaceae family, it is one of the most prominent medicinal and aromatic plants used to treat mild and moderate types of depression. Its pharmacological effect is due to its content of hypericin and its derivatives. The crude drug of this plant is sourced both by collecting (wildcrafting) from the natural populations and by open field production. Plant breeding is aimed at selecting high quality and high yielding varieties that under appropriate climatic conditions and cultivation technologies can ensure sustainable production.

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References

  • Aktan T (2011) Yenişehir (Bursa) köylerinin etnobotanik özellikleri. MSc thesis, Celal Bayar Üniversitesi Fen Bilimleri Enstitüsü, Manisa, Türkiye, 318 pp

    Google Scholar 

  • Albayrak NB (2019) Orhaneli ve Büyükorhan (Bursa) ilçelerinde etnobotanik bir araştırma. MSc thesis, Bursa Uludağ Üniversitesi Fen Bilimleri Enstitüsü, Bursa, Türkiye, 204 pp

    Google Scholar 

  • Alibas I, Kacar O (2016) Microwave drying kinetics, hypericin content, effective moisture diffusivity and activation energy of Hypericum perforatum L. J Essent Oil Bear Plants 19(2):454–446

    Article  CAS  Google Scholar 

  • Aydın S (1990) Hypericum perforatum’un hepatoprotektif etkileri. MSc thesis. Anadolu Üniversitesi Sağlık Bilimleri Enstitüsü, Eskişehir, Türkiye, 50 pp

    Google Scholar 

  • Aydın S, Öztürk Y, Başer KHC, Kırımer N (1992) Hypericum perforatum’un farelerde barbitürat uyku zamanı üzerine etkisi: Hepatoprotektif aktivite. Anadolu Üniversitesi IX. Bitkisel İlaç Hammaddeleri Toplantısı, Bildiriler, 16–19 Mayıs 1991, Eskişehir, p 223–229

    Google Scholar 

  • Ayran I (2021) Geleneksel tıp uygulamalarında kullanılan sarı kantaron (Hypericum perforatum L.) yağının standardizasyonunun belirlenmesi. PhD thesis, Selçuk Üniversitesi, Fen Bilimleri Enstitüsü, Konya, Türkiye, 115 pp

    Google Scholar 

  • Başer KHC (2007) Sarı Kantaron (Hypericum perforatum L.). Anadolu Üniversitesi Eczacılık Fakültesi, Bağbahçe 13

    Google Scholar 

  • Bayram E (2020) Kantaron (Kitap Bölümü). Doğadaki Hazine. TOÇ BİR-SEN, Semih Ofset, Ankara, p 81–97

    Google Scholar 

  • Bayram E, Arabacı O, Çakmak HE (2002) Bornova ekolojik koşullarında Hypericum perforatum L. klonlarının agronomik özelliklerinin ve hiperisin oranlarının belirlenmesi. Ege Üniversitesi, Ziraat Fakültesi Dergisi 39(3):41–48

    Google Scholar 

  • Bayram E, Geren H, Avcı AB, Arabacı O (2004) Farklı kökenli bazı sarı kantaron (Hypericum perforatum L.) populasyonlarının verim ve kalite özellikleri. Ege Üniversitesi, Ziraat Fakültesi Dergisi 41(2):49–58

    Google Scholar 

  • Baytop T (1999) Türkiye’de Bitkiler ile Tedavi, Geçmişte ve Bugün (İlaveli İkinci Baskı). Nobel Tıp Kitapevi, 166 pp

    Google Scholar 

  • Benigni R, Capra C, Cattorini PE (1971) Hypericum. Piante Medicinali: Chimica, Farmacologia e Terapia. Inverni & Della Beffa, Milano

    Google Scholar 

  • Berghöfer R, Hölz J (1986) Johanniskraut (Hypericum perforatum). In: http://res2.agr.gc.ca/london/pmrc/english/study/stjohnswort.html

  • Bilia AR, Gallori S, Vincieri FF (2002) St. John’s wort and depression: efficacy, safety and tolerability-an update. Life Sci 70(26):3077–3096

    Article  CAS  PubMed  Google Scholar 

  • Bombardelli E, Morazzoni P (1995) Hypericum perforatum. Fitoterapia 66:43–68

    CAS  Google Scholar 

  • Bomme U (1983) Versuche zur Einflößung der Keimfähigkeit von Johanniskraut (Hypericum perforatum L.). Versuchsergebnisse Heil-und Gewürzpflanzen der Bayerischen LBP, Freising –Weihenstephan, 38–42

    Google Scholar 

  • Bomme U (1997) Produktion Technologie von Johanniskraut (Hypericum perforatum L.). Z Arznei und Gewürzpflanzen 2(3):127–134

    Google Scholar 

  • Bomme U (2000) Kulturanleitung für Johanniskraut (Hypericum perforatum L.). Drogenreport 5:H-7, 15–18

    Google Scholar 

  • Branther A, Kartnig T, Quehenberger F (1994) Comparative phytochemical investigations of Hypericum perforatum L. and Hypericum maculatum Crantz. Sci Pharm 62:261–276

    Google Scholar 

  • Braunewell H (1991) Ökologische, ontogenetische und morphogenetische Einflüsse auf Ertrag und Inhaltsstoffgehalt von Hypericum ssp. (Johanniskraut). Aus dem Institut fur Pflanzenbau und Pflanzenzüchtung I der Justus-Liebig Univ. Gießen, (Dr. Agr.), 252 pp

    Google Scholar 

  • Briskin DP (2000) Medicinal plants and phytomedicines. Linking plant biochemistry and physiology to human health. Plant Physiol 124:507–514

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bulut GE (2008) Bayramiç (Çanakkale) yöresinde etnobotanik araştırmalar. PhD Thesis, Marmara Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul, Türkiye, 440 pp

    Google Scholar 

  • Büter B, Orlacchio C, Soldati A, Berger K (1998) Significance of genetic and environmental aspects in the field cultivation of Hypericum perforatum. Planta Med 64:431–437

    Article  PubMed  Google Scholar 

  • Butterweck V, Petereit F, Winterhoff H, Nahrstedt A (1998) Solubilised hypericin and pseudohypericin from H. perforatum exert antidepressant activity in the forced swimming test. Planta Med 64:291–294

    Article  CAS  PubMed  Google Scholar 

  • Çakmak EH, Bayram E (2003) Muğla orijinli sarı kantaron (Hypericum perforatum L.) popülasyonlarının bazı agronomik ve kalite özelliklerinin belirlenmesi. Ege Üniversitesi Ziraat Fak Dergisi 40(1):57–64

    Google Scholar 

  • Can Z (2019) Karaman İli’nde kullanılan bitkisel halk ilaçları. MSc Thesis, Karamanoğlu M Üniversitesi Fen Bilimleri Enstitüsü, Karaman, Türkiye, 73 pp

    Google Scholar 

  • Cecchini C, Cresci A, Coman MM, Ricciutelli M, Sagratini G, Vittori S, Lucarini D, Maggi F (2007) Antimicrobial activity of seven Hypericum entities from central Italy. Planta Med 73(06):564–566

    Article  CAS  PubMed  Google Scholar 

  • Ceylan A, Bayram, E, Arabacı O, Marquard R, Özay N, Geren H (2002) Ege Bölgesi florası kantaron (Hypericum perforatum L.) populasyonlarında uygun kemotiplerin belirlenmesi ve ıslahı. TUBİTAK, Proje No: TARP-1991, 75 pp

    Google Scholar 

  • Çırak C, Kurt D (2014) Önemli tıbbi bitkiler olarak Hypericum türleri ve kullanım alanları. Anadolu J AARI 24(1):38–52

    Google Scholar 

  • Çırak C, Kurt D (2016) Chemical content variations of Hypericum perforatum growing in Turkey during its ontogenetic and diurnal cycles. Res Rev J Bot 5(1):1–12

    Google Scholar 

  • Çırak C, Ayan A, Kevseroğlu K (2004) The effects of light and some presoaking treatments on germination rate of St. John’s wort (Hypericum perforatum L.) seeds. Pak J Biol Sci 7:182–186

    Article  Google Scholar 

  • Çırak C, Radusienë J, Karabük B (Sağlam), Janulis V, Ivanauskas L (2007a) Variation of bioactive compounds in Hypericum perforatum growing in Turkey during its phenological cycle. J Integr Plant Biol 49(5):615–620

    Article  Google Scholar 

  • Çırak C, Radušienė J, Karabük B (Sağlam), Janulis V (2007b) Variation of bioactive substances and morphological traits in Hypericum perforatum populations from Northern Turkey. Biochem Syst Ecol 35(7):403–409

    Article  Google Scholar 

  • Crockett SL, Norman K, Robson B (2011) Taxonomy and chemotaxonomy of the genus Hypericum. Med Aromat Plant Sci Biotechnol 5(Special Issue 1):1–13

    PubMed  PubMed Central  Google Scholar 

  • Crompton CW, Hall IV, Jensen KIN, Hildebrand PD (1988) The biology of Canadian weeds. 83. Hypericum perforatum L. Can J Plant Sci 68:149–162

    Article  Google Scholar 

  • Çubukçu B, Meriçli AH, Mat A, Sarıyar G, Sütlüpınar N, Meriçli F (2002) Fitoterapi. İstanbul Üniversitesi yayınları N:4311, Eczacılık Fakültesi Yay., İstanbul 79, 46 pp

    Google Scholar 

  • DAC (Deutscher Arzneimittel Codex) 1986, 3. Ergänzung (1991) Johanniskraut-Hyperici herba. J-010, Frankfurt am Main: Govi Verlag

    Google Scholar 

  • Dachler M, Pelzmann H (1999) Arznei-und Gewürzpflanzen, Anbau, Ernte und Aufbereitung Österreichischer Agrarverlag Klosterneuburg, p 353

    Google Scholar 

  • Darlington CD, Wylie AP (1955) Chromosome atlas of flowering plants. George Allen- Unwin LTD, London, p 519

    Google Scholar 

  • Davis PH (1967) Flora of Turkey and the East Aegean Islands, vol 2. Edinburg University Press, pp 355–401

    Google Scholar 

  • De Smet PA, Mohen WA (1996) St. John’s wort as an antidepressant. Brit Med J 313:241–242

    Article  PubMed  PubMed Central  Google Scholar 

  • Debrunner N, Rauber AL (2000) First report of St. John’s wort anthracnose caused by Colletotrichum gloeosporioides in Switzerland. Plant Dis 84(2):203

    Article  CAS  PubMed  Google Scholar 

  • Delaey M, Kamuhabwa R, Vanderbogaerde AL, Witte PA (1999) Phototoxicity of protohypericin after photoconversion to hypericin. Planta Med 65:719–722

    Article  CAS  PubMed  Google Scholar 

  • Eroğlu Özkan E, Demirci B, Ünsal Gürer Ç, Kültür Ş, Mat A, Başer KHC (2013) Essential oil composition of five endemic Hypericum species from Turkey. Med Aromat Plants 2(2):1–4

    Google Scholar 

  • Freytag EW (1984) Bestimmung von hypericin und Nachweis von pseudohypericin in Hypericum perforatum L. durch HPCL. Deutsch Apoth Ztg 124:2383–2386

    CAS  Google Scholar 

  • Fröbus I, Plescher A (1995) Entwicklung eines wirkstoffoptimierten Johanniskrautes (Hypericum perforatum L.). Arznei-und Gew Thüringen. Jahresbericht:86–96

    Google Scholar 

  • Gaedcke F (1997) Johanniskraut und dessen Zubereitungen, qualitätsbeurteilung über ein selektives reproduzierbares HPLC verfahren. Deutsch Apoth Ztg 137:117–121

    Google Scholar 

  • Galambosi B (1993) Consideration and experience regarding the cultivation of medicinal wild flowers in Finland. Aquilo ser Botanica 31:161–166

    Google Scholar 

  • Gaudchau M, Schneider M, Pank F (1996) Investigation of heavy metal accumulation in various medicinal plants and linseed. In: Proceedings international symposium. Breeding research on medicinal and aromatic plants, 30 June – 4 July 1996, Quedlinburg, Germany, 2(1):381–384

    Google Scholar 

  • Gerders R (1980) The complete book of herbs and herb growing. Ward Lock Limited, London, p 149

    Google Scholar 

  • Geren H (2003) Farklı kökenli sarı kantaron (Hypericum perforatum L.) tiplerinin adaptasyonu ve ontogenetik varyabilitesi. PhD thesis. Ege Üniversitesi Fen Bilimleri Enstitüsü, İzmir, Türkiye, 86 pp

    Google Scholar 

  • Güzel A, Akyüz M, Şanda MA (2019) Determination of antioxidant activity of Hypericum perforatum. Bütünleyici ve Anadolu Tıbbı Dergisi 1(1):9–18

    Google Scholar 

  • Hölz J, Ostrowski E (1987) Johanniskraut (Hypericum perforatum L.) HPLC-analyse der wichtigen Inhaltsstoffe und deren Variabilität in einer Population. Deutsch Apoth Ztg 23:1227–1230

    Google Scholar 

  • ISTA (2014) International rules for seed testing, Published by the International Seed Testing Association, Chapter 5, p 45

    Google Scholar 

  • Jensen KIN, Gaul SO, Specht EG, Doohan DJ (1995) Hypericin content of Nova Scotia biotypes of H. perforatum L. Can J Plant Sci 75:923–926

    Article  CAS  Google Scholar 

  • Kaçar O (2003) Sarı kantaron (Hypericum perforatum L.)’da morfolojik agronomik ozellikler ile hyperisin ve ucucu yağ bakımından bireysel varyabilitenin belirlenmesi. PhD Thesis, Uludağ Üniversitesi Fen Bilimleri Enstitüsü, Bursa, Türkiye,182 pp

    Google Scholar 

  • Kaçar O, Azkan N (2004) Sarı Kantaron’da (Hypericum perforatum L.) hiperisin ve üst drog herba verimi ile bazı morfolojik ve agronomik özellikler arasındaki ilişkiler. Uludağ Üniversitesi Ziraat Fakültesi Dergisi 18(2):109–122

    Google Scholar 

  • Kaçar O, Azkan N (2005a) Türkiye’de bulunan bazı Hypericum (Hyperiaceae) türleri üzerinde sayısal taksonomik bir çalışma. Fırat Üniversitesi Fen ve Mühendislik Bilimleri Dergisi 17(2):424–434

    Google Scholar 

  • Kaçar O, Azkan N (2005b) Bursa’da doğal florada bulunan sarı kantaron (Hypericum perforatum L.) populasyonlarında farklı yüksekliklerin hiperisin oranı üzerine etkisinin belirlenmesi. Uludağ Üniversitesi Ziraat Fakültesi Dergisi 19(1):77–89

    Google Scholar 

  • Kaçar O, Azkan N (2007) Ülkemizdeki farklı kaynaklı sarı kantaron (Hypericum perforatum L.) populasyonlarında hiperisin oranı ve agronomik özellikler bakımından ontogenetik varyabilitenin belirlenmesi. Türkiye VII. Tarla Bitkileri Kongresi, Erzurum, Türkiye, Cilt II, p 543–547

    Google Scholar 

  • Kaçar O, Göksu E, Azkan N (2008) Effects of morphogenetic and diurnal variability on the hypericin content in St. John’s Wort (Hypericum perforatum L.). Afr J Biotechnol 7(13):2163–2168

    Google Scholar 

  • Kaçar O, Göksu E, Azkan N (2011) Bursa ekolojik koşullarında bazı sarı kantaron (Hypericum perforatum L.) çeşit ve populasyonlarının tarımsal özelliklerinin ve hiperisin oranlarının belirlenmesi. Türkiye IX. Tarla Bitkileri Kongresi, Bursa. Türkiye, Cilt II, p 1197–1202

    Google Scholar 

  • Kızılarslan Ç (2008) İzmit Körfezi’nin güney kesiminde etnobotanik bir araştırma. MSc thesis, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul, Türkiye, 291 pp

    Google Scholar 

  • Koçyiğit M (2005) Yalova İli’nde etnobotanik bir araştırma. MSc thesis, İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü, İstanbul, Türkiye, 176 pp

    Google Scholar 

  • Kootstra A, Florack DEA, Gilissen LJW, Bouwmeester HJ, Booij R, Bino RJ (2001) Plants for food and health. Plant Research International B.V Year Book, Wageningen, June 2001, Netherlands

    Google Scholar 

  • Kordana S, Zalecki R (1997) Research on the cultivation of Hypericum perforatum L. Hortic Abstr 67(9):801

    Google Scholar 

  • Kramer W, Wiartalla R (1992) Bestimmung von naphthodianthrone (gesamt Hypericin) in Johanniskraut (Hypericum perforatum L.). Pharm Ztg Wiss 137:202–207

    Google Scholar 

  • Kroth E, Steinhoff B (1998) Johanniskraut: Anbauempfehlungen und Qualitätsanforderungen. Z Arzn Gew Pfl 3:36–50

    Google Scholar 

  • Lieres VA (1989) Die Wirkung von Boden und N-Düngung auf sieben verschiedene heil- und Gewürzpflanzen in Gefaessversuch. Kali-Briefe 19:517–533

    Google Scholar 

  • Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D (1996) St. John’s Wort for depression-an overview and meta-analysis of randomised clinical trials. Brit Med J 313:253–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lurtz U, Plescher A (1997) Einfluss von organischer und mineralischer Düngung auf ertrag und Qualität von Johanniskraut (Hypericum perforatum L.). Drogenreport 10:28–31

    Google Scholar 

  • Mabey E, Mc. Intyre M, Michael P, Duff G, Stevens J (1988) The new age herbalist. Collier Books/Macmillan Publishing Company, p 61

    Google Scholar 

  • Maisenbacher J, Schmidt U, Schenk N (1995) Therapie mit Hypericum bei Angstzustanden. TW Neurologie Psychiatrie 9:65–70

    Google Scholar 

  • Marburg JH (1993) İnhaltsstoffe und wirkmechanismen des Johanniskrautes. Ztschr f Phytother 14:255–264

    Google Scholar 

  • Marquard R, Kroth E (2001) Anbau und Qualitätsanforderungen Ausgewählter Arzneipflanzen-Agrimedia GmbH

    Google Scholar 

  • Meusel H, Jager E, Rauschert S, Weinert E (1978) Vergleichende Chronologie der Zentral europäischen Flora, Band 2. Gustav Hischer Verlag Jen

    Google Scholar 

  • Müldner H, Zöller M (1984) Antidepressive Wirkung eines auf den Wirkstoff komplex hypericin standardisierten Hypericum-extraktes. Arzneim-Forsch/Drug Res 34(8):918–920

    Google Scholar 

  • Murrey MT (1995) The healing power of herbs. U.S.A. p 294

    Google Scholar 

  • Mutlubaş H, Özdemir ZÖ (2020) Hypericum perforatum’un geleneksel tıp alanındaki uygulamaları. Bütünleyici ve Anadolu Tıbbı Dergisi 1(3):10–22

    Google Scholar 

  • Nahrstedt A, Butterweck W (1997) Biologically active and other chemical constituents of the herb from Hypericum perforatum L. Pharmacopsychiatry 30:129–134

    Article  CAS  PubMed  Google Scholar 

  • Newall CA, Anderson LA, Phillipson JD (1983) Herbal medicines. The Pharmaceuticals Press, London, p 250

    Google Scholar 

  • Nia RA (2004) Geliştirilmiş Hypericum perforatum L. klonlarında bazı agronomik ve teknolojik özelliklerin belirlenmesi üzerine araştırmalar. PhD thesis, Ege Üniversitesi Fen Bilimleri Enstitüsü, İzmir, Türkiye, 171 pp

    Google Scholar 

  • Nia RA, Bayram E (2005) Geliştirilmiş sarı kantaron (Hypericum perforatum L.) klonlarının bazı agronomik ve teknolojik özellikleri. Ege Üniversitesi Ziraat Fakültesi Dergisi 42(2):11–22

    Google Scholar 

  • Okpanyi SN, Weischer M, Weischer L (1987) Tierexperimentelle Untersuchungen zur psychotropen Wirksamkeit eines Hypericum-Extractes (Psychotomin M). Arzneim-Forsch/Drug Res 37:10–13

    CAS  Google Scholar 

  • Osbourn AE, Lanzotti V (2009) Plant-derived natural products. Springer, p 200

    Book  Google Scholar 

  • Öztürk Y, Aydın S, Başer KHC, Kırimer N, Kurtaröztürk N (1992) Hepatoprotective activity of Hypericum perforatum L. alcoholic extract in rodents. Phytother Res 6:44–46

    Article  Google Scholar 

  • Özyurt MS (1992) Ekonomik Botanik. Erciyes Üniversitesi Yayınları, No: 47, Kayseri, Türkiye, 190 pp

    Google Scholar 

  • Palevitch D (1991) Agronomy applied to medicinal plant conservation. In: Akerele O, Heywood V, Syng H (eds) The conservation of medicinal plants. Cambridge University Press, Cambridge, pp 167–178

    Chapter  Google Scholar 

  • Patocka J (2003) The chemistry, pharmacology, and toxicology of the biologically active constituents of the herb Hypericum perforatum L. J Appl Biomed 1:61–70

    Article  CAS  Google Scholar 

  • Plescher A (1997) Effizienter und umweltgerechter Anbau von Johanniskraut (Hypericum perforatum L.). Drogenreport 10(17):22–26

    Google Scholar 

  • Pluhár Zs, Bernáth J (2000) Variability of production biological properties at different drug types of Hypericum perforatum L. populations. Lippay János and Vas Károly Scientific Symposium, 6–7 November 2000. Section of Medicinal Plant Sciences: 227 p

    Google Scholar 

  • Pluhár ZS, Rehák O, Németh É (2000) Comparative investigation on Hypericum perforatum L. populations of different origin. Int J Hortic Sci 6(1):56–60

    Google Scholar 

  • Pluhár ZS, Bernáth J, Neumayer É (2001) morphological, production, biological and chemical diversity of St. John’s Wort (Hypericum perforatum L.). In: Proceedings of the international conference on medical and aromatic plants possibilities and limitations of medicinal and aromatic plant production in the 21 st century, 8–11 July, Budapest, Hungary

    Google Scholar 

  • Polat R (2010) Havran ve Burhaniye (Balıkesir) çevresinde tarımsal biyoçeşitlilik ve etnobotanik araştırmaları. PhD thesis, Balıkesir Üniversitesi Fen Bilimleri Enstitüsü, Balıkesir, Türkiye, 359 pp

    Google Scholar 

  • Porter B, McVicar R, Bader L (1998) St. John’s wort in Saskatchewan. Saskatchewan Agriculture, Food and Rural Revitalization. In: http://www.agr.gov.sk.ca/docs/crops/special_crops/production_information/johnswort02.asp;verified (Last access, 28 January 2004)

  • Schneider M, Marquard R (1996) Aufnahme und Akkumulation von Kadmium und weiterer Schwermetalle bei Hypericum perforatum L. und Linum usitatisimum L. Z Arznei-und Gewürzpflanzen 1:111–116

    Google Scholar 

  • Schneider M, Marquard R, Craker LE, Nolan L, Shetty K (1996) Investigations on the uptake of cadmium in Hypericum perforatum L. (St. John’s wort). Acta Hortic 426:435–441

    Article  CAS  Google Scholar 

  • Seçmen Ö, Gemici Y, Görk G, Bekat L, Leblebici E (1995) Tohumlu Bitkiler Sistematiği. Ege Üniversitesi Fen Fakültesi Kitaplar Serisi No: 116, 396 pp

    Google Scholar 

  • Seçmen Ö, Gemici Y, Görk G, Bekat L, Leblebici E (1997) Türkiye Sulak Alan Bitkileri ve Bitki Örtüsü. Ege Üniversitesi Fen Fakültesi Yayınları, No: 158, İzmir, p 74–75

    Google Scholar 

  • Sezik E, Yeşilada E, Honda G, Takaishi Y, Takeda Y, Tanaka T (2001) Traditional medicine in Turkey 10: folk medicine in Central Anatolia. J Ethnopharmacol 75:95–115

    Article  CAS  PubMed  Google Scholar 

  • Sezik E, Yeşilada E, Demirezer Ö (2004) Hızlandırılmış Fitoterapi, Meslek İçi Eğitim Programı Ders Notları. Türk Eczacılar Birliği, Eczacılık Akademisi

    Google Scholar 

  • Shabani A, Karapandzova M, Karanfilova IC, Stefkov G, Crcarevska MS, Kulevanova S (2019) Distribution of total phenols, flavonoids and hypericin in different plant organs of wild-growing St. John’s-wort (Hypericum perforatum L., Hypericaceae) from North Macedonia. Maced Pharm Bull 65(2):39–47

    Article  Google Scholar 

  • Solomon D, Adams J, Graves N (2013) Economic evaluation of St. John’s Wort (Hypericum perforatum) for the treatment of mild to moderate depression. J Affect Disord 148:228–234

    Article  PubMed  Google Scholar 

  • Southwell IA, Bourke CA (2001) Seasonal variation in hypericin content of Hypericum perforatum L. (St. John’s Wort). Phytochemistry 56:437–441

    Article  CAS  PubMed  Google Scholar 

  • Southwell IA, Campell MH (1991) Hypericine content variation in Hypericum perforatum in Australia. Phytochemistry 30(2):475–478

    Article  CAS  Google Scholar 

  • Sun P, Kang T, Xing H, Zhang Z, Yang D, Zhang J, Paré PW, Li M (2019) Phytochemical changes in aerial parts of Hypericum perforatum at different harvest stages. Rec Nat Prod 13(1):1–9

    Article  Google Scholar 

  • Tanker M, Tanker N (1985) Farmakognozi. Ankara Üniversitesi Eczacılık Fakültesi Yayınları 1(58):177 p

    Google Scholar 

  • Tanker N, Koyuncu M, Coşkun M (1998) Farmasötik Botanik Ankara Üniversitesi Eczacılık Fakültesi Yayınları No:78: 278

    Google Scholar 

  • Trifunovic S, Vajs V, Macura S, Juranic N, Djarmati Z, Jankov R, Milosavljevic S (1998) Oxidation products of hyperforin from Hypericum perforatum. Phytochemistry 49:1305–1310

    Article  CAS  PubMed  Google Scholar 

  • Tükel T, Hatipoğlu R (2001) Çayır-Meralarda zehirli bitkiler ve hayvanlar üzerindeki etkileri. Tarım Köy Dergisi, p 139

    Google Scholar 

  • Upton R (1997) St. John’s Wort Monograph in American Herbal Pharmacopoeia. Herbalgram 40:2–31

    Google Scholar 

  • URL (2022a) In: https://bizimbitkiler.org.tr/yeni/demos/technical/ (Last access, 28 June 2022)

  • URL (2022b) TUBIVES. Türkiye Bitkileri Veri Servisi (Turkish Plants Data Service). In: http://194.27.225.161/yasin/tubives/index.php?sayfa=karsilastir (Last accsess, 28 June 2022)

  • Üstün Ç (1998) Santral Sinir Sistemine Etkili Tıbbi Bitkilerin Tarihsel Süreç İçinde ve Günümüz Tedavisindeki Yeri. PhD thesis, Ege Üniversitesi Sağlık Bilimleri Enstitüsü, Deontoloji ve Tıp Tarihi Programı, İzmir, Türkiye 168 pp

    Google Scholar 

  • Uzun F (2009) Ontogenic changes in hypericin content of some Hypericum species in natural pastureland of Turkey. Bangladesh J Bot 38:13–18

    Google Scholar 

  • Verotta L, Anpendino G, Jakupovic J, Bombardelli E (2000) Hyperforin analogues from St. John’s Wort (Hypericum perforatum). J Nat Prod 63:412–415

    Article  CAS  PubMed  Google Scholar 

  • Walker L, Sirvent T, Gibson D, Vance N (2001) Regional differences in hypericin and pseudohypericin concentrations and five morphological traits among Hypericum perforatum plants in the northwestern United States. Can J Bot 79(10):248–1255

    Google Scholar 

  • Wichtl M (1986) Hypericum perforatum L. Das Johanniskraut. Z. f. Phytotherapie 3:87–90

    Google Scholar 

  • Wichtl M, Czygan FC, Frohne D (1984) Teedrogen, Stuttgart, Wissenschaftliche Verlagsgesellschaft. 178 pp

    Google Scholar 

  • Zeybek U, Haksel M (2011) Türkiye’de ve Dünya’da önemli tıbbi bitkiler ve kullanımları. Argefar- Helvacızade Sağlık Yayınları −1 (İkinci Baskı), 222 pp

    Google Scholar 

  • Zeybek N, Zeybek U (1994) Farmasötik Botanik. Ege Universitesi Eczacılık Fakultesi Yayınları No:2, 436 pp

    Google Scholar 

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Kaçar, O., Bayram, E. (2023). Traditional Uses and Cultivation of St. John’s Wort (Hypericum perforatum L.) in Türkiye. In: Máthé, Á., Turgut, K. (eds) Medicinal and Aromatic Plants of Turkey . Medicinal and Aromatic Plants of the World, vol 10. Springer, Cham. https://doi.org/10.1007/978-3-031-43312-2_8

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