Skip to main content

Pimpinella anisum L. (Apiaceae/Umbelliferae)

(Syn.: Anisum vulgare Gart.)

  • Chapter
  • First Online:
Handbook of 200 Medicinal Plants
  • 281 Accesses

Abstract

An annual herb, a native of Egypt, but cultivated in Iran, India, Mediterranean region, and Europe. Ibn al-Baitar, quoting Dioscorides, said that the fruits (seeds) are diuretic, carminative, analgesic, anti-inflammatory, diaphoretic, galactagogue, and aphrodisiac. According to Razi, it is useful in ascites and relieves flatulence and borborygmus, and Avicenna called Anisun deobstruent for kidney, bladder, liver and uterine obstructions, useful in chronic fevers and swelling of face and feet. Ibn Jazlah described Anisun as fennel seeds, with a sweet taste, causes constipation, and is used to prevent obstruction of liver, and as antidote against poisons. Ibn Buţlān used it for cold stomach, against flatulence, and considered it diuretic, to relieve constipation, to increase postpartum milk production, and to improve eyesight. In Unani medicine, the fruits are included in diets of patients suffering from paralysis, facial palsy and epilepsy. Anise water and oil are topically applied to head in headache and to abdomen in flatulence and intestinal colic. Anise was not known to Hindu physicians and was introduced in India by Muslim physicians from Persia. In Iranian traditional medicine, the fruits are used as carminative, aromatic, disinfectant, antimicrobial, galactagogue, antioxidant, anticonvulsant, analgesic and muscle relaxant, and anise oil for treatment of convulsions. In Cayenne and French Guiana, whole plant is used as carminative and vermifuge, while the flowers and seeds decoctions are used for gas pain by Guyana Patamona people. The plant is used for respiratory disorders in Upper Egypt. In addition to anethol-glycol, creosol, anethol, acetaldehyde, isoamylamine, umbelliferone, bergaptene, isopimpinellin, isobergaptene and sphondin, anise seeds (fruit) contain protein, fat, carbohydrate, fiber, and minerals. The flavonoids reported include, quercetin-3-glucoronide, rutin, luteolin 7-glucoside, isoorientin, isovitexin, apigenin 7-glucoside, and a luteolin glycoside. Aqueous and ethanol extracts significantly increased milk production in rats by 68 and 81%, respectively. The weight gain by pups during the study period was correlated with the milk production. Aqueous suspension of powdered seeds (fruit) exhibited significant cytoprotective and antiulcer activities against gastric lesions. In a double-blind RCT of patients with functional dyspepsia, symptoms and quality of life were highly significantly improved after 12-weeks of treatment with anise powder.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 299.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 379.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Abdul-Hamid M, Gallaly SR. Ameliorative effect of Pimpinella anisum oil on immunohistochemical and ultrastuctural changes of cerebellum of albino rats induced by aspartame. Ultrastruct Pathol. 2014;38:224–36.

    Article  Google Scholar 

  2. AbouZid SF, Mohamed AA. Survey on medicinal plants and spices used in Beni-Sueif, Upper Egypt. J Ethnobiol Ethnomed. 2011;7:18.

    Google Scholar 

  3. Ado MA, Abas F, Mohammed AS, Ghazali HM. Anti- and pro-lipase activity of selected medicinal, herbal and aquatic plants, and structure elucidation of an antilipase compound. Molecules. 2013;18:14651–69.

    Article  CAS  Google Scholar 

  4. Al Mofleh IA, Alhaider AA, Mossa JS, et al. Aqueous suspension of anise Pimpinella anisum protects rats against chemically induced gastric ulcers. World J Gastroenterol. 2007;13:1112–8.

    Article  Google Scholar 

  5. Al-Bayati FA. Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. J Ethnopharmacol. 2008;116:403–6.

    Article  CAS  Google Scholar 

  6. Albert-Puleo M. Fennel and anise as estrogenic agents. J Ethnopharmacol. 1980;2:337–44.

    Article  CAS  Google Scholar 

  7. Asadollahpoor A, Abdollahi M, Rahimi R. Pimpinella anisum L. fruit: chemical composition and effect on rat model of nonalcoholic fatty liver disease. J Res Med Sci. 2017;22:37.

    Google Scholar 

  8. Bang J, Mortensen OS, Ebbehøj N. Poisoning by anis oil. Ugeskr Laeger. 2008;170:461 (Danish).

    Google Scholar 

  9. Boskabady MH, Ramazani-Assari M. Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism(s). J Ethnopharmacol. 2001;74:83–8.

    Article  CAS  Google Scholar 

  10. Burkhardt G, Reichling J, Martin R, Becker H. Terpene hydrocarbons in Pimpinella anisum L. Pharmaceutisch Weekblad—Scientific Edition. 1986;8:190–3.

    Article  CAS  Google Scholar 

  11. Changizi-Ashtiyani S, Seddigh A, Najafi H, et al. Pimpinella anisum L. ethanolic extract ameliorates the gentamicin-induced nephrotoxicity in rats. Nephrology (Carlton). 2017;22:133–8.

    Google Scholar 

  12. Chaudhry NM, Tariq P. Bactericidal activity of black pepper, bay leaf, aniseed and coriander against oral isolates. Pak J Pharm Sci. 2006;19:214–8.

    PubMed  Google Scholar 

  13. Darwish RM, Aburjai TA. Effect of ethnomedicinal plants used in folklore medicine in Jordan as antibiotic resistant inhibitors on Escherichia coli. BMC Complement Altern Med. 2010;10:9.

    Google Scholar 

  14. Fitsiou E, Mitropoulou G, Spyridopoulou K, et al. Phytochemical profile and evaluation of the biological activities of essential oils derived from the Greek aromatic plant species Ocimum basilicum, Mentha spicataPimpinella anisum and Fortunella margarita. Molecules. 2016;21. pii: E1069.

    Google Scholar 

  15. Fujimatu E, Ishikawa T, Kitajima J. Aromatic compound glucosides, alkyl glucoside and glucide from the fruit of anise. Phytochemistry. 2003;63:609–16.

    Article  CAS  Google Scholar 

  16. Gamberini MT, Rodrigues DS, Rodrigues D, Pontes VB. Effects of the aqueous extract of Pimpinella anisum L. seeds on exploratory activity and emotional behavior in rats using the open field and elevated plus maze tests. J Ethnopharmacol. 2015;168:45–9.

    Google Scholar 

  17. García-González JJ, Bartolomé-Zavala B, Fernández-Meléndez S, et al. Occupational rhinoconjunctivitis and food allergy because of aniseed sensitization. Ann Allergy Asthma Immunol. 2002;88:518–22.

    Article  Google Scholar 

  18. Gázquez García V, Gaig Jané P, Bartolomé Zavala B. Aniseed-induced nocturnal tongue angioedema. J Investig Allergol Clin Immunol. 2007;17:406–8.

    PubMed  Google Scholar 

  19. Ghoshegir SA, Mazaheri M, Ghannadi A, et al. Pimpinella anisum in modifying the quality of life in patients with functional dyspepsia: a double-blind randomized clinical trial. J Res Med Sci. 2014;19:1118–23.

    PubMed  PubMed Central  Google Scholar 

  20. Giron LM, Freire V, Alonzo A, Caceres A. Ethnobotanical survey of the medicinal flora used by the Caribs of Guatemala. J Ethnopharmacol. 1991;34:173–87.

    Article  CAS  Google Scholar 

  21. Gradinaru AC, Miron A, Trifan A, et al. Screening of antibacterial effects of anise essential oil alone and in combination with conventional antibiotics against Streptococcus pneumoniae clinical isolates. Rev Med Chir Soc Med Nat Iasi. 2014;118:537–43.

    PubMed  Google Scholar 

  22. Hosseinzadeh H, Tafaghodi M, Abedzadeh S, Taghiabadi E. Effect of aqueous and ethanolic extracts of Pimpinella anisum L. seeds on milk production in rats. J Acupunct Meridian Stud. 2014;7:211–6.

    Google Scholar 

  23. Ishikawa T, Fujimatu E, Kitajima J. Water-soluble constituents of anise: new glucosides of anethole glycol and its related compounds. Chem Pharm Bull (Tokyo). 2002;50:1460–6.

    Article  CAS  Google Scholar 

  24. Jamshidzadeh A, Heidari R, Razmjou M, et al. An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity. Iran J Basic Med Sci. 2015;18:205–11.

    PubMed  PubMed Central  Google Scholar 

  25. Janahmadi M, Farajnia S, Vatanparast J, et al. The fruit essential oil of Pimpinella anisum L. (Umblliferae) induces neuronal hyperexcitability in snail partly through attenuation of after-hyperpolarization. J Ethnopharmacol. 2008;120:360–5.

    Google Scholar 

  26. Kačániová M, Vukovič N, Horská E, et al. Antibacterial activity against Clostridium genus and antiradical activity of the essential oils from different origin. J Environ Sci Health B. 2014;49:505–12.

    Article  Google Scholar 

  27. Karimzadeh F, Hosseini M, Mangeng D, et al. Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complement Altern Med. 2012;12:76.

    Google Scholar 

  28. Kassi E, Papoutsi Z, Fokialakis N, et al. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties. J Agric Food Chem. 2004;52:6956–61.

    Article  CAS  Google Scholar 

  29. Kermanshah H, Kamangar SS, Arami S, et al. The effect of hydroalcoholic extract of seven plants on cariogenic bacteria—an in vitro evaluation. Oral Health Dent Manag. 2014;13:395–401.

    PubMed  Google Scholar 

  30. Kitajima J, Ishikawa T, Fujimatu E, et al. Glycosides of 2-C-methyl-D-erythritol from the fruits of anise, coriander and cumin. Phytochemistry. 2003;62:115–20.

    Article  CAS  Google Scholar 

  31. Koch C, Reichling J, Schneele J, Schnitzler P. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine. 2008;15:71–8.

    Article  CAS  Google Scholar 

  32. Kosalec I, Pepeljnjak S, Kustrak D. Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharm. 2005;55:377–85.

    Google Scholar 

  33. Kreydiyyeh SI, Usta J, Knio K, et al. Aniseed oil increases glucose absorption and reduces urine output in the rat. Life Sci. 2003;74:663–73.

    Article  CAS  Google Scholar 

  34. Kunzemann J, Herrmann K. Isolation and identification of flavon(ol)-O-glycosides in caraway (Carum carvi L.), fennel (Foeniculum vulgare Mill.), anise (Pimpinella anisum L.), and coriander (Coriandrum sativum L.), and of flavon-C-glycosides in anise. I. Phenolics of spices (author’s transl). Z Lebensm Unters Forsch. 1977;164:194–200 (German).

    Google Scholar 

  35. Lee JB, Yamagishi C, Hayashi K, Hayashi T. Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. Biosci Biotechnol Biochem. 2011;75:459–65.

    Article  CAS  Google Scholar 

  36. Mahady GB, Pendland SL, Stoia A, et al. In vitro susceptibility of Helicobacter pylori to botanical extracts used traditionally for the treatment of gastrointestinal disorders. Phytother Res. 2005;19:988–91.

    Article  Google Scholar 

  37. Nahidi F, Kariman N, Simbar M, Mojab F. The study on the effects of Pimpinella anisum on relief and recurrence of menopausal hot flashes. Iran J Pharm Res. 2012;11:1079–85.

    PubMed  PubMed Central  Google Scholar 

  38. Nickavar B, Abolhasani FA. Screening of antioxidant properties of seven umbelliferae fruits from Iran. Pak J Pharm Sci. 2009;22:30–5.

    CAS  PubMed  Google Scholar 

  39. Orav A, Raal A, Arak E. Essential oil composition of Pimpinella anisum L. fruits from various European countries. Nat Prod Res. 2008;22:227–32.

    Google Scholar 

  40. Pourgholami MH, Majzoob S, Javadi M, et al. The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. J Ethnopharmacol. 1999;66:211–5.

    Article  CAS  Google Scholar 

  41. Robles-Zepeda RE, Velázquez-Contreras CA, Garibay-Escobar A, Gálvez-Ruiz JC, Ruiz-Bustos E. Antimicrobial activity of Northwestern Mexican plants against Helicobacter pylori. J Med Food. 2011;14:1280–3.

    Article  Google Scholar 

  42. Sahraei H, Ghoshooni H, Hossein Salimi S, et al. The effects of fruit essential oil of the Pimpinella anisum on acquisition and expression of morphine induced conditioned place preference in mice. J Ethnopharmacol. 2002;80:43–7.

    Article  CAS  Google Scholar 

  43. Samojlik I, Mijatović V, Petković S, et al. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia. 2012;83:1466–73.

    Google Scholar 

  44. Samojlik I, Petković S, Stilinović N, et al. Pharmacokinetic herb-drug interaction between essential oil of aniseed (Pimpinella anisum L., Apiaceae) and acetaminophen and caffeine: a potential risk for clinical practice. Phytother Res. 2016;30:253–9.

    Google Scholar 

  45. Sawalha AF, Sweileh WM, Zyoud SH, Jabi SW. Self-therapy practices among university students in Palestine: focus on herbal remedies. Complement Ther Med. 2008;16:343–9.

    Article  Google Scholar 

  46. Shahamat Z, Abbasi-Maleki S, Mohammadi Motamed S. Evaluation of antidepressant-like effects of aqueous and ethanolic extracts of Pimpinella anisum fruit in mice. Avicenna J Phytomed. 2016;6:322–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  47. Shojaii A, Abdollahi Fard M. Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharm. 2012;2012:510795.

    PubMed  PubMed Central  Google Scholar 

  48. Shreaz S, Bhatia R, Khan N, et al. Exposure of Candida to p-anisaldehyde inhibits its growth and ergosterol biosynthesis. J Gen Appl Microbiol. 2011;57:129–36.

    Article  CAS  Google Scholar 

  49. Singh G, Kapoor IP, Pandey SK, et al. Studies on essential oils: part 10; antibacterial activity of volatile oils of some spices. Phytother Res. 2002;16:680–2.

    Article  CAS  Google Scholar 

  50. Soliman KM, Badeaa RI. Effect of oil extracted from some medicinal plants on different mycotoxigenic fungi. Food Chem Toxicol. 2002;40:1669–75.

    Article  CAS  Google Scholar 

  51. Tavallali V, Rahmati S, Bahmanzadegan A. Antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum L. as affected by zinc fertilizer. J Sci Food Agric. 2017;97:4883–9.

    Google Scholar 

  52. Topal U, Sasaki M, Goto M, Otles S. Chemical compositions and antioxidant properties of essential oils from nine species of Turkish plants obtained by supercritical carbon dioxide extraction and steam distillation. Int J Food Sci Nutr. 2008;59:619–34.

    Article  CAS  Google Scholar 

  53. Truhaut R, Le Bourhis B, Attia M, et al. Chronic toxicity/carcinogenicity study of trans-anethole in rats. Food Chem Toxicol. 1989;27:11–20.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Shahid Akbar .

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Akbar, S. (2020). Pimpinella anisum L. (Apiaceae/Umbelliferae). In: Handbook of 200 Medicinal Plants. Springer, Cham. https://doi.org/10.1007/978-3-030-16807-0_146

Download citation

Publish with us

Policies and ethics